Senin, 26 Januari 2015

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"The finest writer of paperback originals in America today." - Stephen King

“[O]ne of the best writers of horror in this or any other country.” - Peter Straub

“One of the genre’s most underrated writers . . . enjoyably nasty.” - Poppy Z. Brite

“A must-read for horror fiction fans. . . . Obtain The Amulet by any means necessary.” - Too Much Horror Fiction

“McDowell has a flair for the gruesome.” - Washington Post

When a rifle range accident leaves Dean Howell disfigured and in a vegetative state, his wife Sarah finds her dreary life in Pine Cone, Alabama made even worse. After long and tedious days on the assembly line, she returns home to care for her corpselike husband while enduring her loathsome and hateful mother-in-law, Jo. Jo blames the entire town for her son’s mishap, and when she gives a strange piece of jewelry to the man she believes most responsible, a series of gruesome deaths is set in motion. Sarah believes the amulet has something to do with the rising body count, but no one will believe her. As the inexplicable murders continue, Sarah and her friend Becca Blair have no choice but to track down the amulet themselves, before it’s too late . . .

Michael McDowell (1950-1999) is best known for his screenplays to the films Beetlejuice and The Nightmare Before Christmas, but he was also the author of several excellent and underrated Southern Gothic horror novels, of which The Amulet (1979) was the first. Originally published as a pulp paperback, now scarce and long out-of-print, McDowell’s grimly humorous and delightfully horrific novel returns to print in this edition, which features a new introduction by Poppy Z. Brite.

  • Sales Rank: #211706 in eBooks
  • Published on: 2013-11-07
  • Released on: 2013-11-07
  • Format: Kindle eBook

Most helpful customer reviews

30 of 31 people found the following review helpful.
The first novel of Michael McDowell; unsung American author.
By Miguel
"The Amulet", first published in 1979, was Michael McDowell's first paperback original. It set the pace for what was to be a marvelous career, including several other novels, such as "Cold Moon Over Babylon", "The Elementals", "Katie", "Gilded Needles" and the successful serial novel "Blackwater", to which Stephen King gives credit as his main inspiration for the "Green Mile" series.
Also, as a footnote, Michael McDowell was the creator of the screenplay and characters of the hugely successful "Beetlejuice" movie.
Set in the summer of 1965, at the dawn of the Vietnam war, this is the haunting story of a sleepy southern town called Pine Cone, and what went on there... After her husband is the casualty of a bizarre accident, young Sarah Howell slowly comes to realize that her strange, treacherous mother-in-law, is somehow behind an infernal plan of revenge.
Slowly, as a pendant in a gold chain passes from hand to hand, citizens of the town begin to die in horrid, violent ways. What is behind this? What leads a loving mother to set her children and home on fire? A dutiful policeman to turn against his wife? A friend against the other?... as the body count rises, Sarah must run against time to stop the accursed amulet... but slowly it seems to be finding her way to her.
Michael McDowell passed away on December 27, 1999. He was a lecturer at Tufts college, a Harvard Graduate and a Brandeis Ph.D... He will be sorely missed on account of his books, wickedly funny, consistently written and beautifully plotted. His characters stay with the reader even long after finishing the book. It's too bad he has been overlooked by many a horror and literature fan, for this si the real stuff... Horror as Modern Literature.

6 of 6 people found the following review helpful.
" This Horror Book is a Classic ",,,,,,,,
By Robin Lee
Micheal McDowell introduced me into the world of horror! You see one side of the house was reading the GoodBook everyday and the other side of the house had stacks and stacks of paperback novels of horror. So, I snuck the book out of my mother's extensive collection and was thrown into a completely different realm. In 1979, this was the first horror book I ever read and I was 14 yrs old. I couldn't put it down then and I can't now, often sometimes comparing his great writing to the new horror authors out there now......

The moment I started reading I was hooked. His writing flowed seamlessly and he was always capable of placing you right into the story itself. You got lost in his world! Every character in this book ends up being connected through an evil, cursed, "chain" of events. It eventually comes full circle in this small town, to it's original owner. A wicked mother out for vengeance for her son............

Needless to say I own all of Micheal McDowell's books and have read them all. All his books were excellent, but my favorite's will always be this one and "The Elementals".......

Sadly, this great author and screenwriter passed away in 1999. I feel he never got a chance to fully achieve the status that other great masters of horror writing did! I have a good friend that's trying to break into horror world, so I found an excellent copy on Amazon, he is 26 yrs and wanted to read the classics. It's very hard to find a copy of any of his books and it takes a lot of searching!! All this author's books are out of print, they are priceless!!!!!

4 of 4 people found the following review helpful.
Couldn't stop reading it.
By Daniel Vullo
I loved the book. I read so much about Michael McDowell from other reviews and I figured I'd give him a go, and he sure doesn't disappoint. The Amulet was relatively short only 340 pages, but it read as if it had so much more vastness. The story of a cursed Amulet that makes its way to person to unrelated person and they in turn kill those around them, sounds hokey, but McDowell makes it plausible with great set ups and back grounds of the characters. The story moves along at a great pace never boring and never slow it is just right, almost as if every sentence and chapter were worded with great skill and construction. The chapters were short concise, and to the point, which made reading that much more enjoyable. Why this story was never made into a great film is beyond me, since it was so compelling a story. As one set of people died and the Amulet moved on, I couldn't wait to see what will happen next, and how their method of death will be explained. Michael McDowell has a very good way of detailing the deaths and he really surprises us by not pulling any punches by killing people that many would say was unexpected, but it works. I first heard of this writer, after I read Duma Key by Stephen King. Someone is a review said that Duma Key was similar to a novel by McDowell called The Elementals, but only that much better. I later learned that Stephen King admired McDowell's work. King's Wife Tabitha even finished McDowell's last novel after his untimely death. With that said i figured he must be a good writer. I went out and purchased all of his known novels, I have Cold Moon over Babylon, The Elementals and The Black Water series complete, so I am really eager to get to his next story, I am glad I can keep such a great writer's memory alive.

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How to you make your site do all those awesome things everyone else does? How do you bail yourself out when you’ve made a mistake? How do you bail your users out, or stop them from shooting themselves in the foot? Can you say ‘no’ to your users?

While it’s an extension of WordPress Multisite 101, 110 isn’t a supplemental, in fact it’s longer than 101! This is the next step for people who’ve managed to get the site up and running, but want to do a little more. In this ebook, there’s more philosophy and discussion, and fewer direct answers, because now you have to make decisions based on the pros and cons. Are you ready?

  • Sales Rank: #1170481 in eBooks
  • Published on: 2014-01-07
  • Released on: 2014-01-07
  • Format: Kindle eBook

Most helpful customer reviews

0 of 0 people found the following review helpful.
Five Stars
By Craig Rippon
Provided all the information I needed to make a decision about using multisite and a successful multisite setup

0 of 1 people found the following review helpful.
Indispensable for Multisite Management
By rgbatson
This book and the previous one (about installation) are superb guides to some of the intricacies of Wordpress Multisite (which should not even be attempted without a grounding in single WP installs). Many issues are identified and dealt with. Numerous plugins are suggested as solutions. Backup, security and maintenance are covered in detail. A myriad of choices for administering the main site and individual sites are clearly explained, with practical pros and cons. A relatively short book, no doubt to again be expanded in the future by a regular WP expert to be found in the forums. A got-to-have-it book.

0 of 1 people found the following review helpful.
lots of good stuff
By NickyB
Mika and Andrea have an easy to read and understand style, I learnt heaps reading this book, keep up the good work

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Minggu, 25 Januari 2015

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  • Sales Rank: #3702425 in Books
  • Published on: 1707
  • Binding: Paperback

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Kamis, 22 Januari 2015

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  • Sales Rank: #1150513 in eBooks
  • Published on: 2011-01-13
  • Released on: 2011-01-13
  • Format: Kindle eBook

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Selasa, 20 Januari 2015

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Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines is a practical guidebook for those engaged in clinical trial design. This book details the organizations and content of clinical trials, including trial design, safety, endpoints, subgroups, HRQoL, consent forms and package inserts. It provides extensive information on both US and international regulatory guidelines and features concrete examples of study design from the medical literature. This book is intended to orient those new to clinical trial design and provide them with a better understanding of how to conduct clinical trials. It will also act as a guide for the more experienced by detailing endpoint selection and illustrating how to avoid unnecessary pitfalls. This book is a straightforward and valuable reference for all those involved in clinical trial design.

  • Provides extensive coverage of the "study schema" and related features of study design
  • Offers a "hands-on" reference that contains an overview of the process, but more importantly details a step-by-step account of clinical trial design
  • Features examples from the medical literature to highlight how investigators choose the most suitable endpoint(s) for clinical trial and includes graphs from real clinical trials to help explain each concept in study design
  • Integrates clinical trial design, pharmacology, biochemistry, cell biology and legal aspects to provide readers with a comprehensive look at all aspects of clinical trials
  • Includes chapters on core material and important ancillary topics, such as package inserts, consent forms, and safety reporting forms used in the United States, England and Europe

For complimentary access to our sample chapter (chapter 24), please copy and paste this link into your browser: http://tinyurl.com/awwutvn

  • Sales Rank: #1181673 in Books
  • Published on: 2011-11-25
  • Original language: English
  • Dimensions: 9.50" h x 7.75" w x 1.50" l, 3.17 pounds
  • Binding: Hardcover
  • 638 pages

Review

"…A solid guide to designing clinical trials for medical scientists, especially those working in oncology, immune disease, and infectious disease…Three chapters address quality-of-life topics."  -Selected for The First Clinical Research Bookshelf, "Essential Reading for Clinical Research Professionals," Journal of Clinical Research Best Practices, September 2012, Vol. 8, No. 9

About the Author
Dr. Tom Brody received his PhD from the University of California at Berkeley in 1980, and conducted postdoctoral research at University of Wisconsin-Madison and also at U.C. Berkeley. His 20 research publications concern the metabolism and pharmacology of folates, cloning an anti-cancer gene (XPE gene), and the structure of an antibody (natalizumab) used for treating multiple sclerosis. The author has 15 years of pharmaceutical industry experience, acquired at Schering-Plough, Cerus Corporation, and Elan Pharmaceuticals, and has contributed to FDA submissions for the indications of multiple sclerosis, melanoma, head and neck cancer, liver cancer, pancreatic cancer, and hepatitis C. At an earlier time, he wrote two editions of Nutritional Biochemistry, published by Elsevier, Inc. The author has 16 years of training and experience in the Code of Federal regulations, as it applies to pharmaceuticals and clinical trial design.

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3 of 3 people found the following review helpful.
Comprehensive and well organized. Highly recommended.
By Mara Gil
This is the most comprehensive book on clinical trials I've seen so far.
Touches all key areas of clinical trials conduct; I very much enjoyed (yes, I do enjoy learning about the work I love!) the elaboration on Biomarkers and Endpoints. This manual is useful even for experienced professionals, has chapters to be used as a reference and presents new information as well. Extremely well organized, easy to read and informative, a must for any clinical research professional.

4 of 6 people found the following review helpful.
Quoted from a review originally published in, "Journal of Clinical Research Best Practices" Vol. 8, Sept. 2012
By Tom Brody
The following is a quotation from a review that was published in Journal of Clinical Research Best Practices, Vol. 8, Sept. 2012. The author of this review is Norman M. Goldfarb.

The published review is as follows, and I quote:

"Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines, is a solid guide to designing clinical trials for medical scientists, especially those working in oncology, immune disease, and infectious disease. The statistical chapters are brief and include very few formulae. Three chapters address quality-of-life topics. In addition to the core material, the book also includes chapters on some ancillary topics like patents and package inserts."

[My comment on the above writing is that the chapter on STATISTICS contains seventeen (17) mathematical formulas.]

The published review by Dr. Goldfarb also states, "Essential reading for clinical research professionals."

The published review also reveals this:

"The section on study designs discusses and provides diagrams for 17 schemas. The following text illustrates the book's fairly technical style:

FORWARDS SEQUENCE AND REVERSE SEQUENCE -- THE PUHALLA SCHEMA.

The clinical trial of Puhalla et al. (38) contains two arms (Fig. 2.8). Subjects in the first arm received drugs in this order: D followed by AC. In detail, subjects received docetaxel on the first day of each cycle, for 4 cycles, where each cycle was 14 days long. This was followed by doxorubicin (an anthracycline drug) plus cyclophosphamide, on the first day of each cycle, for 4 cycles. Each cycle was 2 weeks long.

Now, this is about the second arm. Subjects in the second arm received drugs in the reverse order, that is, AC followed by D. The investigators chose a 2-arm study design, where each arm was the reverse of the other, because it was not possible to predict which order would provide the better outcome.

The type of trial design, where one arm uses a "forward sequence" of two drugs, and where another arm uses the "reverse sequence" of the two drugs, sometimes finds a basis in the mechanism of action of certain drugs. The following specifically concerns chemotherapy involving paclitaxel and gemcitabine. As explained by Paccagnella et al. (39) for a clinical trial on lung cancer, "[s]everal reports have shown that the sequence of administration of gemcitabine and paclitaxel may also affect the efficacy of this combination chemotherapy, since paclitaxel increases the concentration of active metabolite of gemcitabine (dFdCTP) when administered first."

To repeat, the above review was written by Norman M. Goldfarb. The complete version of Dr. Goldfarb's review was published in J. Clin. Res. Best Practices, Vol. 8, Sept. 2012.

1 of 3 people found the following review helpful.
Received my book.
By susan hmwe
Hi,

I have received my book. I will recommend this book to anyone who just enters clinical trial industry. Thank you!

See all 3 customer reviews...

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Minggu, 18 Januari 2015

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The finite element method is a technique for solving problems in applied science and engineering. The essence of this book is the application of the finite element method to the solution of boundary and initial-value problems posed in terms of partial differential equations. The method is developed for the solution of Poisson's equation, in a weighted-residual context, and then proceeds to time-dependent and nonlinear problems. The relationship with the variational approach is also explained.

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  • Sales Rank: #3292909 in Books
  • Published on: 2011-11-10
  • Released on: 2011-11-10
  • Original language: English
  • Number of items: 1
  • Dimensions: 6.70" h x .60" w x 9.60" l, 1.05 pounds
  • Binding: Paperback
  • 320 pages

About the Author

Alan Davies is Professor of Mathematics at the University of Hertfordshire where his teaching and research is in numerical applied mathematics. He was the Head of the School of Physics, Astronomy and Mathematics until he retired in 2006 since when he has been able to concentrate on the communication of mathematics and physics through the department's outreach programme.

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Sabtu, 17 Januari 2015

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  • Sales Rank: #9269144 in Books
  • Binding: Hardcover

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